The main objective of the EDCTP programme is to accelerate the development of new or improved medical interventions for poverty-related infectious diseases affecting sub-Saharan Africa. Therefore, EDCTP’s largest investments are awarded to collaborative clinical research on a range of medical interventions, especially diagnostics, and drugs and vaccines for treatment and prevention. These grants support phase I–III safety and efficacy studies, with emphasis on phase II and III trials. Phase IV pharmacovigilance and post-licensing effectiveness studies (pragmatic trials), and product-focused implementation studies are also supported.