EDCTP steers to achieve a balanced project portfolio across the programme’s scope of disease areas: HIV & HIV-associated infections, tuberculosis, malaria, neglected infectious diseases, diarrhoeal diseases, lower respiratory tract infections, and emerging and re-emerging infections relevant to sub-Saharan Africa, including COVID-19, Ebola and yellow fever. The funded activities are well aligned to the EDCTP strategic priorities, especially addressing niche areas such as the development of medical interventions for key populations with major unmet medical needs.