Description

Background

There is a severe shortage of opportunities for junior and mid-career researchers to acquire and develop clinical research skills in sub-Saharan Africa. Increased possibilities for individual training would enable talented scientists to establish themselves as independent researchers and team leaders at host institutions in sub-Saharan Africa.

Scope

The purpose of this Call for Proposals is to provide funding to actions that aim to support junior to mid-career researchers (“fellows”) to train and develop their clinical research skills.

The objectives are:

1. To promote career development and retention of postdoctoral researchers and postgraduate medical researchers in the research field and in sub-Saharan Africa;
2. To equip the fellows with the ability to establish themselves as independent researchers and with the skills to initiate and manage their own research and team at host organisations in sub-Saharan Africa.

The proposed action should specifically enhance the ability of the fellow to design, plan and execute clinical biomedical and/or social science/ethics research projects within the scope of the EDCTP2 programme(1). The proposed training should include an independent research activity and a clear description of the skills that will be acquired by carrying out the research. Fellows with training activities involving clinical trials and related studies must ensure that studies are appropriately designed and good clinical practice (GCP)-compliant and that good manufacturing practice (GMP)-compliant investigational product(s) are available and guaranteed, and all sponsor responsibilities can be fulfilled by the host organisation (applicant legal entity where the fellow is employed) or product developer involved in the project. Individuals targeted by this Call for Proposals should have a track record of publications in peer-reviewed journals in their chosen area of research, a mentor who is an internationally recognised scientific leader working in sub-Saharan Africa, and a career development plan as part of the research proposal.

Application for an EDCTP Career Development Fellowship must be submitted by the prospective fellow in conjunction with and on behalf of their proposed host organisation (‘the applicant legal entity’). The grants are awarded to the host organisation with the explicit commitment that this organisation offers appropriate conditions for the fellow to direct and manage its funding for the duration of the fellowship.

Expected impact

Activities funded under this Call for Proposals will promote career progression, encourage entry and re-integration of African scientists trained abroad, and ensure the retention of postdoctoral and postgraduate researchers in their respective research fields and that the researchers develop into independent researchers and team leaders in sub-Saharan Africa. The progressive generation of independent researchers, re-entry of ones trained abroad and retention of those working in sub-Saharan Africa will ultimately contribute to creation of a critical mass of internationally recognised scientific leaders, institutions and networks that will sustain high quality research in sub-Saharan Africa. The career development fellowship grants will also contribute to reduce and reverse the brain drain of African scientist that moved out of or trained outside Africa by offering an opportunity to return to Africa and progress their career to establish themselves as independent researchers, thereby empowering them to assume a leadership role in clinical research and contributing to sustainable development.

Eligibility

1. The applicant must be an organisation with an established legal entity in sub-Saharan Africa (the applicant legal entity)(2).
2. The fellow must be employed or have guaranteed employment by the applicant legal entity (the host organisation) where they intend to remain working for a minimum of two years after the expiration of the grant(2).
3. Fellows must:(2)

• be a resident of or be willing to relocate to a sub-Saharan African country
• be either a graduate in a subject relevant to the EDCTP2 programme, with a PhD and up to five years’ relevant postdoctoral research experience, or a medical doctor with up to five years’ research experience;
• must not have received funding for this fellowship scheme before.(3)

4. The requested EDCTP contribution per action shall not exceed € 150,000.
5. The maximum fellowship duration shall be 36 months.

Notes

1. For the purpose of this Call for Proposals, PRDs include HIV/AIDS, malaria, tuberculosis; the following neglected infectious diseases (NIDs): dengue/severe dengue, rabies, human African trypanosomiasis (sleeping sickness), Leishmaniases, cysticercosis/taeniasis, dracunculiasis (guinea-worm disease), echinococcosis, food-borne trematodiases, lymphatic filariasis, onchocerciasis (river blindness), schistosomiasis, soil-transmitted helminthiases, Buruli ulcer; leprosy (Hansen disease), trachoma, and yaws; diarrhoeal diseases; lower respiratory tract infections, as well as emerging and re-emerging infectious diseases of particular relevance for Africa, such as Ebola or yellow fever.
2. This additional condition for participation according to RfP Art. 9.5 is required due to the objectives of this Training & Mobility Action. It aims to support junior fellows in sub-Saharan Africa in line with the activities called for by the EU legislator (EDCTP2 basic act, Annex II, activity 1c). It contributes to the specific objectives of the EDCTP2 programme which calls, e.g., for cooperation with sub-Saharan Africa on building their capacity for conducting clinical trials in compliance with fundamental ethical principles, relevant legislation and international standards, and for extended cooperation with private partners (EDCTP2 basic act, Annex I, objectives 2b).
3. This additional condition for participation according to RfP Art. 9.5 is required due to the objectives of the EDCTP2 programme which requires that the capacity for conducting clinical trials in sub-Saharan Africa are built and strengthened (EDCTP2 basic act, Annex II). Allowing fellows in sub-Saharan Africa to only receive once a specific EDCTP2 fellowship will increase the number of different fellows supported and promoted under the EDCTP2 programme, and in turn strengthen more broadly the corresponding clinical research capacity in sub-Saharan Africa.

Procedure and application process

Submission and evaluation procedure

This is a single-stage application procedure. Proposals must be submitted by 28 February 2017 via EDCTPgrants. Applicants will be notified of the outcome by 7 July 2017.

The host organisation (applicant) must provide a support letter confirming that the organisation is supportive of the proposed action and willing through its financial and administrative systems to enable the fellow to direct independently the proposed action and manage its funding for the duration of the fellowship.

Evaluation criteria, scoring and thresholds

Following an admissibility and eligibility check, letters of intent and full proposals are evaluated by external, independent experts. Proposals are evaluated according to the criteria Excellence, Impact and Implementation. Each criterion is scored between 0 and 5.

The following aspects are considered under the evaluation criteria:

1. Excellence

• Fit with the scope and objectives of the EDCTP2 programme and the call topic description.
• Importance, relevance/pertinence and clarity of the objectives.
• Soundness of the concept and credibility of the proposed approach/methodology.
• Suitability of the candidate, considering their track record, degree of independence and/or potential, and how the fellowship will further the individual’s career.
• Quality of the project and its fit with the fellow’s expertise and career development plan, including acquired competencies and skills to be developed further.

2. Impact

• The extent to which the outputs of the proposed work would contribute, at the European, African and/or International level, to each of the expected impacts listed in the work plan under the relevant topic.
• Likelihood to result in major advances for the field.
• Contribution of the fellowship to the fellow’s clinical research skills and career development.
• Contribution to strengthening clinical research capacity at the home or host organisation.
• Effectiveness of the proposed measures to exploit and disseminate results generated during the fellowship (including management of IPR), to communicate the fellowship activities, and, where relevant, to manage clinical data.
• Sustainability and retention of capacity post-award.

3. Quality and efficiency of the implementation

• Quality and effectiveness of the work plan, including extent to which the resources assigned to work packages are in line with their objectives and deliverables.
• Appropriateness of the management structures and procedures, including risk and innovation management, and how responsibilities for research data quality and sharing, and security will be met.
• Complementarity of the participants within the consortium, and the extent to which the consortium as whole brings together the necessary expertise.
• Appropriateness of the allocation of tasks and resources, ensuring that all participants have a valid role and adequate resources in the project to fulfil that role.
• Feasibility and appropriateness of the methods and project management to achieve the objectives within the timeframe of the grant.
• Compliance with national and international standards of research, Good Clinical Practice, ethics and safety related issues.
• Participants have the operational capacity, to carry out the proposed work, based on the competence and experience of the individual participant(s).
• Suitability of the fellow’s home (host) organisation to support the fellowship project.
• Intention of the fellow’s home (host) organisation to develop and commit to a career post-fellowship or re-integration plan.

Financial provisions

The call budget is 2.1 million EUR.

The maximum fellowship duration shall be 36 months and the requested EDCTP contribution should not exceed 150,000 EUR. The funding level is 100% of eligible costs.

Grant agreement

The legal entity employing the successful fellow (‘host organisation’) is required to sign a grant agreement with EDCTP (EDCTP2 mono-beneficiary grant agreement with options for fellowships) within three months of receipt of the conditional award letter.

Application process

• The application must be submitted online via EDCTPgrants
• Only registered users of EDCTPgrants system can apply for grants and therefore you are advised to register on the system as soon as possible

Documents and more information

Documents

• EDCTP2 annual work plan 2016 (PDF)

More information

• For questions related to this call for proposals, please contact: Ms Shingai Machingaidze (machingaidze[at]edctp.org)
• For questions and issues about EDCTPgrants and the online application submission please contact EDCTP via edctpgrants[at]edctp.org or +31 (0) 70 344 08 80.
• For guidance on online application procedure, please refer to the Guidance for applicants.
• For more information about EDCTP2 procedures, please refer to the EDCTP2 Grants Manual and EDCTP2 FAQs

Projects funded under this call

ABOUT
Career Development Fellow: Dr Jane Wanyama
Antiretroviral therapy outcomes, barriers and facilitators of adherence and linkage to care among individuals initiating treatment following test and start guidelines in an urban HIV clinic in Uganda

Infectious Diseases Institute Limited (IDI), Kampala, Uganda 
Starting date: 1 June 2018
Duration: 36 months
Grant amount: EUR 149,891
Grant agreement: TMA2016CDF-1602

ARA
Career Development Fellow: Dr Obinna Ekwunife
Conditional economic incentives and motivational interviewing to improve adolescents’ retention and adherence to antiretroviral therapy in south-east Nigeria: a cluster randomised trial

Nnamdi Azikiwi University (NAU), Enugu, Nigeria 
Starting date: 1 June 2018
Duration: 36 months
Grant amount: EUR 148,782
Grant agreement: TMA2016CDF-1548
Project web page

ChoVaxim
Career Development Fellow: Dr Caroline C. Chisenga
Immunogenicity to cholera vaccine with a population at risk in Zambia: mapping the kinetics of immune responses over time

Centre for Infectious Diseases Research in Zambia Limited (CIDRZ), Lusaka, Zambia
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 149,956
Grant agreement: TMA2016CDF-1550

EBOV-RDT-ROC
Career Development Fellow: Dr Misaki Wayengera
Receiver operator characterisation of novel EBOV/MARV-GP epitopes using 2014-2015 Siera Leonian Ebola patient samples at the NICD BSL-IV

Makerere University, Kampala, Uganda
Starting date: 1 August 2018
Duration: 18 months
Grant amount: EUR 149,688
Grant agreement: TMA2016CDF-1545

ECIP
Career Development Fellow: Dr Sylvie Kwedi
An innovative collaboration model between the national TB control program and informal healthcare providers to detect additional cases of TB in Cameroon

University of Yaounde I, Yaounde, Cameroon
Starting date: 1 August 2018
Duration: 36 months
Grant amount: EUR 149,963
Grant agreement: TMA2016CDF-1570

EDIIMark2
Career Development Fellow: Dr Boris K. Tchounga
Epidemiology, diagnosis algorithms and prognostic role of immunologic and inflammatory markers among HIV-2-infected individuals in West Africa

Association PAC-CI (PAC-CI), Abidjan, Côte d’Ivoire
Starting date: 1 August 2018
Duration: 36 months
Grant amount: EUR 149,958
Grant agreement: TMA2016CDF-1597

ESSLDPQ P4502D6
Career Development Fellow: Dr Richard Mwaiswelo
Single low-dose primaquine efficacy and safety for treatment of uncomplicated Plasmodium falciparum malaria based on cytichrome P450 2D6 activity in Bagamoyo district, Tanzania

Tropical Pesticides Research Institute (TPRI), Ausha, Tanzania
Starting date: 1 August 2018
Duration: 30 months
Grant amount: EUR 148,050
Grant agreement: TMA2016CDF-1555

Evaluate 4mTB
Career Development Fellow: Dr Stephanus Malherbe
Evaluating the response to 4 and 6 month treatment of pulmonary tuberculosis by 18F-FDG PET/CT lung imaging

Stellenbosch University (SU), Stellenbosch, South Africa
Starting date: 1 April 2018
Duration: 48 months
Grant amount: EUR 149,696
Grant agreement: TMA2016CDF-1576

FERDAR
Career Development Fellow: Dr Yunia Mayanja
A prospective cohort study to access the feasibility of enrolling and retaining adolescents at risk of HIV infection from hotspots in Kampala Uganda

Uganda National Health Research Organisation (UNHRO), Entebbe, Uganda
Starting date: 1 August 2018
Duration: 42 months
Grant amount: EUR 149,412
Grant agreement: TMA2016CDF-1574
Project website

Geographical differences in the immune response
Career Development Fellow: Dr Moustapha Mbow
Immune responses in rural to urban gradient: identifying geographical footprints of the immune system to improve vaccine development

Université Cheikh Anta Diop de Dakar (UCAD), Dakar, Senegal
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 148,924
Grant agreement: TMA2016CDF-1595
Project webpage

IPTP-SP+
Career Development Fellow: Dr Jean-Bertin Kabuya
Safety and efficacy of intermittent presumptive treatment with sulphadoxine-pyrimethamine using rapid diagnostic test screening and treatment at first antenatal visit

Tropical Diseases Research Centre (TDRC), Ndola, Zambia
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 149,999
Grant agreement: TMA2016CDF-1584

Kenya CVHIV
Career Development Fellow: Dr Tecla Temu
Inflammation, T Cell activation and sub-clinical atherosclerosis in treated HIV infection

University of Nairobi, Nairobi, Kenya
Starting date: 1 December 2018
Duration: 36 months
Grant amount: EUR 149,000
Grant agreement: TMA2016CDF-1598

Masquisard
Career Development Fellow: Dr Justin Nono Komguep
Identification of host regulators of tissue fibroproliferative pathology in schistosomiasis-diseased children in Africa

University of Cape Town (UCT), Cape Town, South Africa
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 140,277
Grant agreement: TMA2016CDF-1571

MIDAS
Career Development Fellow: Dr Aida Sivro
Mucosal type 1 IFN desensitisation and the risk of HIV acquisition

Centre for the AIDS programme of research in South Africa (CAPRISA), Durban, South Africa
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 150,000
Grant agreement: TMA2016CDF-1582

MyTB
Career Development Fellow: Dr Nelita Du Plessis
Host-directed therapy: Myeloid derived suppressor cell ablation by phosphodiesterase inhibitor

Stellenbosch University (SU), Stellenbosch, South Africa
Starting date: 1 April 2018
Duration: 24 months
Grant amount: EUR 148,627
Grant agreement: TMA2016CDF-1564
webpage

PSOP24-377
Career Development Fellow: Dr Kingsley Badu
PSOP24-377: An infectious bite marker for sensitive malaria detection and population level surveillance

Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 144,500
Grant agreement: TMA2016CDF-1605
AREF news item on fellowship

SAEFRIF
Career Development Fellow: Dr Christine Sekaggya
Safety and efficacy of high-dose rifampicin in TB-HIV co-infected patients on efavirenz-based antiretroviral therapy

Infectious Diseases Institute Limited (IDI), Kampala, Uganda
Starting date: 1 June 2018
Duration: 36 months
Grant amount: EUR 150,000
Grant agreement: TMA2016CDF-1580
See video interview at Ninth EDCTP Forum

SecBILE
Career Development Fellow: Dr Alexander Kwarteng
Impact of secondary bacterial infection in the development of filarial lymphedema among Ghanaian patients

Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 150,000
Grant agreement: TMA2016CDF-1561

SPATOMA
Career Development Fellow: Assistent Prof. Yaya Kassogue
Study of pharmcogenetics of ARVs treatment outcomes in Mali, West Africa

Université des sciences, des techniques et des technologies de Bamako (USTTB), Bamako, Mali
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 147,585
Grant agreement: TMA2016CDF-1566

TRACING
Career Development Fellow: Dr Evaezi Okpokoro
Mycobacterium tuberculosis infection rates among health care workers in a HIV care and treatment centre in Nigeria

Institute of Human Virology Nigeria (IHVN), Abuja, Nigeria
Starting date: 1 July 2018
Duration: 36 months
Grant amount: EUR 150,000
Grant agreement: TMA2016CDF-1583

VXMedSSurv
Career Development Fellow: Dr Dan Kajungu
Vaccines and medicines utilisation and safety monitoring system in a health and demographic surveillance system, Uganda

Makerere University Centre for Health and Population Research Limited (MUCHAP), Iganga, Uganda
Starting date: 1 June 2018
Duration: 36 months
Grant amount: EUR 148,627
Grant agreement: TMA2016CDF-1563
Project website
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